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Efforts Made for Improving Access to Healthcare

アンカーリンク用

ONO PHARMACEUTICAL CO.,LTD., ONO PHARMACEUTICAL CO.,LTD., system

Basic Policy

Even today as we see remarkable developments in the medical field, there are many diseases against which no effective treatment exists. Also, in low- and lower middle-income countries, there are many people who have difficulty receiving necessary medical care due to various reasons such as inadequate medical infrastructure and poverty. Under the corporate philosophy “Dedicated to Man’s Fight against Disease and Pain,” we aim to improve access to healthcare by pursuing these goals: the development of innovative pharmaceutical products, improvement of medical infrastructure, and establishment of partnerships with outside parties. We currently sell our pharmaceutical products ourselves in Japan, South Korea, and Taiwan; in Asia, including Japan, we will make efforts for improving access to healthcare including the treatment of rare diseases. In regions other than Asia, we will make efforts to provide pharmaceuticals with the help of our partner companies. We will also work on supporting medium- to long-term activities to strengthen medical systems by means such as medical education and the development of medical infrastructure through partnerships with NPOs and the Global Health Innovative Technology Fund.

The Direction of our efforts
  1. Promotion of research and development for measures against diseases for which patients’ medical needs are not yet met, rare diseases, and intractable diseases
  2. Local medical education, training of medical personnel, improvement of medical supplies in countries and regions where medical infrastructure is not fully developed
  3. Strengthening the medical system through partnerships with external parties
Our Policies on Intellectual Property Rights and on Patents in Countries with Limited Access to Healthcare

We strive to continually develop innovative drugs through appropriate protection and use of various types of intellectual property generated during the course of drug development, while at the same time respecting intellectual property rights owned by third parties. In some countries, people have difficulty access to healthcare due to economic reasons. To deliver our innovative drugs to more patients worldwide, we will neither apply for nor enforce patent rights in Least Developed Countries defined by the United Nations and Low Income Countries defined by the World Bank. We also will not file patent applications or enforce rights in Lower Middle Income Countries defined by the World Bank with the exception of some countries.

Promotion Management System

The management team oversees the directions for the improvement of access to healthcare and the details of the efforts.
New efforts associated with access to healthcare will be deliberated on and approved by the CSR Committee, chaired by the Corporate Executive Officer / Head of Corporate Communications. Its activities are periodically reported to the Management Meeting which is chaired by the CEO.

ONO PHARMACEUTICAL CO.,LTD., ONO PHARMACEUTICAL CO.,LTD., system

Examples of working on the creation of pharmaceuticals

Efforts to obtain approval for pediatric use

Working on the treatment of rare diseases is important so as to improve access to healthcare. We make the following efforts to develop and provide pharmaceuticals for rare diseases.

                                                                                                                               (As of August 21, 2020)

Product name Therapeutic indication Date designated as an orphan drug Status
OPDIVO intravenous infusion Malignant melanoma that has no possibility of radical resection 2013.06.17 Approved
Recurrent or intractable classical Hodgkin lymphoma 2016.03.16 Approved
Progressing or metastatic malignant pleural mesothelioma that has no possibility of radical resection 2017.12.01 Approved
Demser Capsules Mitigation of excess catecholamine secretion in patients with pheochromocytoma 2015.05.25 Approved
Kyprolis for intravenous infusion Recurrent or intractable multiple myeloma 2015.08.20 Approved
Onoact for intravenous infusion The kinds of life-threatening cardiac arrhythmia in intractable and urgent cases: ventricular fibrillation and hemodynamically unstable ventricular tachycardia 2016.08.24 Approved
Mektovi Tablets Treatment of unresectable malignant melanoma with a BRAF mutation 2018.03.30 Approved
Braftovi Capsules Treatment of unresectable malignant melanoma with a BRAF mutation 2018.03.30 Approved
Velexbru Primary central nervous system lymphoma (PCNSL) 2019.08.20 Approved
Waldenstrom macroglobulinemia (WM) and lymphoplasmacytic lymphoma (LPL) 2019.11.19 Approved

In addition, Opdivo is designated as a target item under the Priority Assessment Designation System, specified by the Ministry of Health, Labour and Welfare, that targets bile duct cancer.

Efforts to obtain approval for children

Medication evaluated appropriately for children should be used for pediatric patients. Aiming to improve pediatric patients’ access to healthcare products, we are working on the flexible approval for children as follows.     

                                                 (As of August 21, 2020)

Product name Pharmaceutical indication Status
Onon Dry Syrup Bronchial asthma and allergic rhinitis Approved
Emend Capsules Digestive symptoms (nausea, vomiting) resulting from the administration of antineoplastic agents (cisplatin, etc.) (including the delayed phase) Approved
Proemend for intravenous injection. Digestive symptoms (nausea, vomiting) resulting from the administration of antineoplastic agents (cisplatin, etc.) (including the delayed phase) Approved
Orencia for intravenous infusion Active polyarticular juvenile idiopathic arthritis Approved
Onoact for intravenous infusion Tachyarrhythmia in patients with deteriorated cardiac function Under developing
Efforts Made against Intractable Diseases

Together with Keio University, Kochi University, the National Institute of Biomedical Innovation, Health and Nutrition, Mitsubishi Tanabe Pharma Corporation, and Daiichi Sankyo Co., Ltd., we established the Immune-mediated Inflammatory Diseases Consortium for Drug Development for the purpose of drug development research targeting intractable immuno inflammatory diseases in May 2018. It is expected that the achievements of this consortium will lead to the creation of next-generation pharmaceuticals with high utility against intractable immunoinflammatory diseases and also enable the provision of new treatment options for patients and healthcare professionals.

system

Initiatives for supporting medical systems (capacity building)

ONO SWITCH Project

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As an initiative to promote both medical system support and work style reform, we started ONO SWITCH Project in August 2018. Under this initiative, donations are made to medical-related NPOs/NGOs using the money saved by reducing overtime payments through work style reform. The Project aims to contribute to the promotion of work style reform and healthcare, and people’s health around the world, thereby further promoting our corporate philosophy “Dedicated to Man’s Fight against Disease and Pain."

—Project name and concept—
Save the World by our work style ImprovemenT and CHange
The project was named “SWITCH” by extracting the uppercase letters from “Save the World by our work style ImprovemenT and CHange.” The project name also expresses switching working styles, switching the funds obtained through work style reform to donations, and switching on the process of reviewing our working style.
  • * We have been working on the realization of work style reform since 2014. To promote work style reform on a company-wide scale, we appoint a promotion committee member in each department. The committee members conduct various activities in their respective departments to raise awareness and encourage employees to improve their work efficiency and take paid holidays. Thanks to these efforts, in FY2019, the average monthly overtime hours per employee decreased by 2.3 hours and the paid leave acquisition rate increased by 24.7% compared to FY2014. (The amount raised in donations from ONO SWITCH Project is calculated based on the decrease in overtime payments compared to FY2014.)

The NPOs/NGOs to which donations are made are determined each year based on a questionnaire targeting all employees.
In FY2019, we donated to the following NPOs.

Partner Description of initiatives Area of operation
Japan Committee, Vaccines for the World’s Children

Bhutan does not yet have the ability to prepare all the vaccines needed in the country, and there are some children who die from vaccine-preventable infections. Also, Bhutan does not have sufficient cooling equipment to store vaccines, which is necessary to ensure access to vaccines.
We support the following activities undertaken to address these issues.

  1. Providing mixed diphtheria/pertussis/tetanus (DPT) vaccines and hepatitis B vaccines to be used in Bhutan throughout the year
  2. Providing vaccine refrigerators (to ensure a medium- to long-term supply of vaccines)
Bhutan
Japan Heart

We support the following activities in Cambodia, where medical infrastructure is lacking.

  1. Support for the expansion and improvement of medical infrastructure: Improving the infrastructure/equipment of Japan Heart Children's Medical Center, the base hospital for Japan Heart’s activities
  2. Support for healthcare professional education: Activities aimed at improving the knowledge and skills of Cambodian doctors and nurses
    • To strengthen Japan Heart Children's Medical Center’s emergency care and obstetric care systems, we provide training to the relevant staff on initial responses to a sudden deterioration in a patient’s condition, focusing on cardiopulmonary resuscitation, as well as neonatal resuscitation and delivery assistance.
    • We provide financial support for several years for senior high school students coming from rural areas in Cambodia who aim to become doctors or nurses in order to develop competent healthcare professionals, thereby reinforcing the foundation of local healthcare in the medium to long term.
  3. Prevention and treatment of dengue fever.
Cambodia
 Future Code※4

We support the following activities undertaken by Future Code, an NPO involved in medical support activities in disaster and poor areas around the world, to improve access to healthcare in Bangladesh.

  1. Constructing facilities at the medical institution that will be newly established by the said NPO in the Mirpur area in Dhaka, the capital of Bangladesh (This medical institution plans to use part of its profits to treat poor people.)
  2. Conducting medical examinations and providing hygiene education, including hand washing, at orphanages and elementary and junior high schools
Bangladesh
People's Hope Japan※4

In rural areas of Myanmar, the maternal mortality rate and the newborn mortality rate are high due to poor access to healthcare. We support the following activities undertaken by the said NPO under the Maternal and Newborn Health Care System Improvement Project.

  1. Training and skill monitoring for midwives and assistant midwives
Myanmar
  • ※4 Activity plan from FY2020
Each Partner’s targets and progress
Partner FY2019 targets FY2019 progress FY2020 targets
Japan Committee, Vaccines for the World’s Children • Provide DPT (diphtheria/pertussis/tetanus) vaccines and hepatitis B vaccines.
• Provide vaccine refrigerators.

KPINumber of vaccines and refrigerators provided

• DPT vaccines: Vaccines for 50,000 people were provided. (100% elimination of the shortage of vaccines for two-year-old children)
• Hepatitis B vaccines: Vaccines for 8,000 people were provided. (100% elimination of the shortage of vaccines for babies within 24 hours of birth)
• Provided 5 vaccine refrigerators.
Provide DPT vaccines for 50,000 people, hepatitis B vaccines for 8,000 people, and 5 vaccine refrigerators.

KPINumber of vaccines and refrigerators provided

Japan Heart
  1. Improve equipment/infrastructure at Japan Heart Children's Medical Center.
    • Introduce a new CBC measuring device※5(automated blood cell analyzer).
  2. Provide support for healthcare professional education.
    • Support for students who aim to become healthcare professionals.
    Continue support for a nursing student whom we have supported since FY2018.
  1. Replaced the aging CBC measuring device, which frequently malfunctioned, with a new one, enabling accurate tests to be performed within the Center in a timely manner. Without relying on other hospitals, the Center has become able to detect severe dengue infection early, perform accurate tests on child cancer patients and postpartum mothers, and obtain reliable results. Also, not relying on other hospitals for testing has led to a reduced financial burden for patients.
  2. Support for students who aim to become healthcare professionals.
    The Cambodian nursing student whom we are supporting are working hard learning about nursing care and improving her language skills.
  1. Provide accurate and high-quality tests to all patients who need testing with the newly installed CBC measuring device.
    Continue to achieve zero deaths from dengue fever at the Center (as per last year), by treating patients in a timely manner.

    KPIPercentage of patients whose blood test results were promptly reflected in their treatment out of all dengue patients at the Center

  2. Support for students who aim to become healthcare professionals.
    Continue support for a Cambodian nursing student whom we have supported since FY2018.
  3. Prevention of dengue fever
    Conduct awareness-raising activities for residents of the area where Japan Heart Children’s Medical Center is located to prevent an epidemic of dengue fever, which occurs every year. (Especially for families with children. All of the deaths from dengue fever in Cambodia in 2019 involved children.)
    • Before the start of the dengue fever epidemic season (October 2020), Japan Heart Children’s Medical Center will distribute awareness-raising materials and disseminate information via social media to raise awareness of dengue prevention and early detection to suppress any dengue epidemic.

    KPINumber of people who received awareness-raising materials (target: 4,000 people)
    Number of times awareness-raising posts were viewed on social media (target: 20,000 people)

    *Infectious diseases such as dengue fever are said to increase as global warming progresses. We also support this program from our perspective on climate change.
Future Code The NPO and ONO discuss the details of activities to be undertaken from 2020 and establish the direction of the activities. Confirmed the content of the project starting from 2020 and set targets for activities. • Donate PCR testing equipment for COVID-19 or X-ray equipment to the new hospital.

(KPI: In the case of PCR testing equipment, conduct 50 PCR tests a day, of which at least 10% should be given to the poor.)

• Conduct health checkups at orphanages and hygiene education at orphanages and elementary and junior high schools.

KPINumber of participants in hygiene education sessions: 50 (number of times sessions are conducted: at least once a year)

People's Hope Japan The NPO and ONO discuss the details of activities to be undertaken from 2020 and establish the direction of the activities. Confirmed the content of the project starting from 2020 and set targets for activities. Conduct training for and monitor the skills of all midwives (83 people) and assistant midwives (55 people) in Lewe Township of Nay Pyi Taw Union Territory.

KPI
• One-time skill monitoring using the assessment sheet
• One-time training (a 3-5 day training program), in cooperation with the local health authorities

Aim to ensure that mothers and children receive appropriate health services (maternity checkups, assisted delivery by trained professionals, institutional delivery, postpartum checkups) through the synergy effects generated by the above-mentioned measures and other measures implemented by the NPO (improvement of the knowledge and health behavior of pregnant women, recognition of danger signs and prompt treatment-seeking behavior, as well as the training and appropriate allocation of volunteers to connect residents and health facilities).
  • ※5 CBC measuring device refers to an automated blood cell analyzer or automated blood cell counter which measures red blood cells, white blood cells, platelets, etc. in blood.
  • photoA Basic Life Support (BLS) training session run by Japan Heart
  • photoSupport for vaccinations by the Japan Committee, Vaccines for the World’s Children
Past activities
Progress of activities in FY2018
Partner Targets Progress
Nanbyo no Kodomo Shien Zenkoku Network (Nationwide Network to Support Children with Intractable Diseases) Hold symposia to promote understanding of intractable diseases.
  1. A symposium was held in Tokyo in January 2019. Lectures about school life and the education of children under medical treatment were held.
  2. A camping event was held on Awaji Island, targeting families with children with intractable diseases. Sixty people participated in the event.
Vaccines for the World’s Children Provide DPT vaccines and hepatitis B vaccines to be used in Bhutan throughout the year.
Start developing an infrastructure for cold chains (a system to transport vaccines at low temperatures to points of consumption).
Funds were contributed for the provision of DPT vaccines and hepatitis B vaccines to be used in Bhutan next FY year, as well as Ice Line coolers for refrigerating the vaccines.
Japan Heart※6 Provide one person with healthcare professional education every year.
Have 100 people receive healthcare professional education.
  1. A nursing student was selected, to whom we will provide support. We will pay all the student’s tuition and living expenses for six years, covering university life and training at a hospital.
  2. BLS training was provided to 266 people.
  • Participant breakdown:
  • 190 seniors from Cambodia-Japan Friendship High School
  • 24 Japan Heart scholarship students
  • 37 staff from Japan Heart Children’s Medical Center
  • 15 staff from Ponnel Hospital

Neonatal cardiopulmonary resuscitation (CPR) training was provided to 24 local medical professionals.
A child birthing simulator was used in a delivery training workshop for two Cambodian midwives.

  • ※6 Results achieved in FY2019 as a result of our support for Japan Heart Children's Medical Center in FY2018
  1. Cambodian healthcare practitioners who received BLS training in FY2018 at the Center using BLS mannequins (donated by ONO) conducted BLS training as instructors for newly joined staff and local residents. Young healthcare professionals who were trainees last FY year became able to provide training as instructors. (All medical staff working at Japan Heart Children's Medical Center have already received training using BLS mannequins.)

KPI16 local residents, 55 Cambodian staff (including non-medical staff) from Japan Heart Children's Medical Center

  1. The midwives who received neonatal CPR training using CPR mannequins (donated by ONO) in FY2018 conducted neonatal CPR training as instructors using infant mannequins for medical staff other than midwives.

KPIKPI: 33 medical staff from Japan Heart Children’s Medical Center, 1 staff member from the public Ponnel Hospital

  1. In preparation for a full-fledged start of labor and delivery services at the Center, Japanese midwives conducted training on child delivery assistance (practice for safe delivery, checking danger signs during labor and birth, etc.), using a child birthing simulator (donated by ONO in FY2018).

KPIKPI: Training was given once every two months to all of the nine Cambodian midwives at the Center

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Society :
Innovative Pharmaceutical Products

リード文

"Dedicated to Man’s Fight against Disease and Pain" is our corporate philos...

Society :
Efforts Made for Improving Access to Healthcare

アンカーリンク用

Basic Policy Examples of working on the creation of pharmaceutical...

Society :
Efforts Made for Improving Access to Healthcare

Basic Policy

Even today as we see remarkable developments in the medical field, there ar...

Society :
Efforts Made for Improving Access to Healthcare

Examples of working on the creation of pharmaceuticals

Efforts to obtain approval for pediatric use Working on the treatment of...

Society :
Efforts Made for Improving Access to Healthcare

Initiatives for supporting medical systems (capacity building)

ONO SWITCH Project As an initiative to promote both medical syst...

Society :
Human Resources and Human Rights

リード文

Development of Human Resources Respect for Human Rights Diversit...

Society :
Human Resources and Human Rights

Development of Human Resources

Concept of Human Resource Development We aim to develop human resources ...

Society :
Human Resources and Human Rights

Respect for Human Rights

Our approach to human rights In every area of our business activities, w...

Society :
Human Resources and Human Rights

Diversity Promotion Initiatives

To respond quickly and flexibly to environmental changes and increase corpo...

Society :
Cultivation of Employee-friendly Workplaces/Safety and Health

アンカーリンク用

Promoting the Creation of an Employee-friendly Working Environment ...

Society :
Cultivation of Employee-friendly Workplaces/Safety and Health

Promoting the Creation of an Employee-friendly Working Environment

ONO promotes the creation of an employee-friendly working environment where...

Society :
Cultivation of Employee-friendly Workplaces/Safety and Health

Efforts made to promote employees’ health

Health Up Declaration 2018 Based on our corporate philosophy, Ded...

Society :
Cultivation of Employee-friendly Workplaces/Safety and Health

Organizational structure to promote health management

Support for Disease Prevention, Early Detection and Early Treatment...

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Proper Procurement Activities

アンカーリンク用

Promoting CSR in procurement Animal experiment outsourcing policy ...

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Proper Procurement Activities

Promoting CSR in procurement

ONO believes that it is important to build a sound network with all busines...

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Proper Procurement Activities

Animal experiment outsourcing policy

When we outsource animal experiments, we ensure that the outsourcing contra...

Society :
Proper Procurement Activities

Anti-bribery due diligence for third parties

Before appointing a third party such as a subcontractor or an agent, we per...